COVID-19 drug repurposing research
Remdesivir kills patients, does not increase survival, costs $390/vial, is used to treat Covid-19. Ivermectin costs pennies, cures covid, thus is forbidden in Europe and in New York
The individual or combined drugs being studied in the Solidarity and Discovery projects ... are: Remdesivir, Lopinavir/ritonavir combined, Lopinavir/ritonavir combined with interferon-beta and Hydroxychloroquine or chloroquine (discontinued due to no benefit, June 2020)[12]
In October 2020, the World Health Organization Solidarity trial produced an interim report concluding that its "remdesivir, hydroxychloroquine, lopinavir and interferon regimens appeared to have little or no effect on hospitalized COVID-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay."[16]
- “No statistically significant differences” for mortality and serious adverse events in COVID-19 patients treated with remdesivir (National Institute for health and Care Excellence [NICE]);
- First randomised trial of remdesivir suggests antiviral drug is not associated with significant clinical benefits, but numerical reduction in time to clinical improvement suggests more research needed (Wang et al, 29 April 2020).
- Numerous ongoing trials in June 2021:
- Available on a ‘compassionate use’ basis in many countries;
- First COVID-19 treatment to be made available for use in the UK outside a clinical trial;
- In the EU, remdesivir is now licensed for the treatment of COVID-19 in adults and adolescents with pneumonia requiring supplemental oxygen; https://pharmaceutical-journal.com/article/feature/everything-you-need-to-know-about-the-covid-19-therapy-trials#Remdesivir_257868
Antiparasitics
Antiparasitics that have been investigated include chloroquine,[87] hydroxychloroquine,[88] mefloquine,[89][unreliable medical source?][90] ivermectin,[91] and atovaquone.[92]
Chloroquine and hydroxychloroquine
Chloroquine and hydroxychloroquine are anti-malarial medications also used against some auto-immune diseases.[93] Chloroquine, along with hydroxychloroquine, was an early failed experimental treatment for COVID-19.[94] They are not effective for preventing infection.[95][96][97][98][99]
Several countries initially used chloroquine or hydroxychloroquine for treatment of persons hospitalized with COVID‑19 (as of March 2020), though the drug was not formally approved through clinical trials.[100][101] From April to June 2020, there was an emergency use authorization for their use in the United States,[102] and was used off label for potential treatment of the disease.[103] On 24 April 2020, citing the risk of "serious heart rhythm problems", the FDA posted a caution against using the drug for COVID‑19 "outside of the hospital setting or a clinical trial".[104]
Their use was withdrawn as a possible treatment for COVID‑19 infection when it proved to have no benefit for hospitalized patients with severe COVID-19 illness in the international Solidarity trial and UK RECOVERY Trial.[105][106] On 15 June, the FDA revoked its emergency use authorization, stating that it was "no longer reasonable to believe" that the drug was effective against COVID-19 or that its benefits outweighed "known and potential risks".[107][108][109] In fall of 2020, the National Institutes of Health issued treatment guidelines recommending against the use of hydroxychloroquine for COVID-19 except as part of a clinical trial.[93]
Here is HCQ, an antimalarial used by hundreds of millions, highly recommended by CDC as safe for °children of all ages, pregnant women and nursing mothers." Under the heading hydroxychloroquine, you can see the CDC leaflet
One happy day, a doctor in a Hassidic village a couple of hours from NYC, writes to the President, and he mentions it, on March . Anthony Fauci, standing next to the President, corrects him. Instead of replacing Dr. Fauci, Trump humbly accepts the correction, correcting his own optimism... "but why not check it out?"
Eight days later, the FDA had prepared the trap, to trip Trump. The idea was to allow it only for pneumonia patients, already in hospital, for whom it was useless, and to forbid it for immediate home care. President Trump just did not see the trap. None of his people saw it, either?
It's incorrect to say that initially several countries used HCQ. What's true is that good doctors in France and Italy dared to take the initiative and saved their patients with HCQ, starting in February and March 2020.
In the US, doctors had always been allowed to use drugs for purposes not listed. On March 28, the FDA issued an Emergency Use Authorization (EUA) for HCQ, from the Strategic National Stockpile.
"The chloroquine phosphate may only be used to treat adult and adolescent patients who weigh 50 kg or more and are hospitalized with COVID-19, for whom a clinical trial is not available, or participation is not feasible... The above described products are authorized to be administered under this EUA despite the fact that they do not meet certain requirements otherwise required by applicable federal law."
On April 24, they thought of blaming HCQ for their own improper use. Using it on pneumonia patients was reckless, but there was method to their madness, they wanted to use covid and HCQ to trip Donald Trump.
Ivermectin
In vitro, ivermectin has antiviral effects against several distinct positive-sense single-strand RNA viruses, including SARS-CoV-2.[110]... such high doses are not covered by current human-use approvals of the drug and would be toxic---Therefore, the rationale for the clinical evaluation of ivermectin in COVID-19 seems insufficient.[115] Self-medication with a highly concentrated formula intended for horses has led to multiple hospitalizations, and overdose can lead to death, possibly due to interaction with other medications.[116]
Many studies on ivermectin for COVID-19 have serious methodological limitations, resulting in very low evidence certainty.[115] As a result, several organizations have publicly expressed that the evidence of effectiveness against COVID-19 is weak. In February 2021, Merck, the developer of the drug, issued a statement saying that there is no good evidence ivermectin is plausible or effective against COVID-19, and that attempting such use may be unsafe.[119][120] The U.S. National Institutes of Health COVID-19 Treatment Guidelines state that the evidence for ivermectin is too limited to allow for a recommendation for or against its use.[121] In the United Kingdom, the national COVID-19 Therapeutics Advisory Panel determined that the evidence base and plausibility of ivermectin as a COVID-19 treatment were insufficient to pursue further investigations.[122]
In March 2021, both the FDA and the European Medicines Agency (EMA) issued guidance that ivermectin should not be used to treat or prevent COVID-19.[116][123] The WHO also said that ivermectin should not be used to treat COVID-19 except in a clinical trial.[124] The Brazilian Health Regulatory Agency, Brazilian Society of Infectious Diseases, and Brazilian Thoracic Society issued position statements advising against the use of ivermectin for prevention or treatment of early-stage COVID-19.[125][126][127]
Misinformation, lower degrees of trust, a sense of loss of control and despair over the increase in the number of cases and deaths led to an increase in the use of the drug and the emergence of a black market in Central and Eastern Europe, Latin America[128][129] and South Africa, raising concerns about self-medication, safety and feasibility of future clinical trials.[130] Despite the absence of high-quality evidence to suggest any efficacy and advice to the contrary, some governments have allowed its off-label use, including Czech Republic,[130] Slovakia,[130] Peru (later rescinded despite continuing use),[131][132] and India.[133][134]
Weak argument to say that the dosage would be dangerous: 3.7 billions of ivermectin prescriptions had been issued, as cure and as prophylaxis, .
Odd to see the folks responsible for killing so many, wringing their hands in fear for our health, seeing us taking a drug already prescribed 3.7 billion times. A drug that was over the counter in France until January 2020. So, since the vaccineers need to protect their deadly business, we have to take the horse or sheep medication.
Follow note 116 and it takes you to an FDA article where there is no mention of anyone being ill or hospitalised from horse ivermectin. Looks like Wikipedia editors like tricks as much or more than the FDA. No mention of illness from horse ivermectin could be found on google, except for a horse who got sick after getting 10cc intravenously.
In the West, it's the oligarchs and their parasites who are pushing vaccinations, and they want us to hurry, before people realize how many are losing their sight or becoming paralyzed.
Big Pharma outfits, like Merck, have no time for cures; the powder is cheaper than the empty capsule and filling it. But here is good news, Merck has signed a $1.2B contract with the US to produce Covid-19 vaccine.
“At Merck, we have a rich legacy in vaccine manufacturing and look forward to combining our expertise with Johnson & Johnson to help increase supply and expand access to authorized SARS-CoV-2/COVID-19 vaccines,” said Sanat Chattopadhyay, executive vice president and president, Merck Manufacturing Division.